COMT — Catechol-O-methyltransferase
COMT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COMT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Basement Membrane ECM ECM production | BSG, COL6A1, COL6A2, ECE1, ECM1, FNDC3B, LAMB1, LAMC1 +2 more | View in SCUBA |
| Glial cells | Glial Myelination Identity Myelination | AP1S2, CALM2, CD81, CD9, GPM6B, GSN, IGFBP7, LGALS1 +6 more | View in SCUBA |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, CTSS +35 more | View in SCUBA |
| Smooth muscle cells | Redox-Metabolic Housekeeping Housekeeping | DAD1, GSTO1, NDUFB5, POR, PREPL, PSMA5, SEC61B | View in SCUBA |
About the gene
| Chromosome | 22: 19941371-19969975 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
| Biological process | Catecholamine metabolism, Lipid metabolism, Neurotransmitter degradation |
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.