SCUBA

CTSS — Cathepsin S

CTSS belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CTSS's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsMHC-II antigen presentation
B cell maturation
ARID5A, CD52, CD74, CD79A, CYBA, HLA-DPA1, HLA-DPB1, HLA-DQA1 +9 moreView in SCUBA
CD4⁺ T cellsChromatin Regulation
DNA/chromatin regulation
ADI1, ASXL2, BTG3, CASP8, CHD3, CWF19L2, DENND2D, DNTTIP2 +17 moreView in SCUBA
EndothelialComplement Innate Immune
Inflammation
C1R, C1S, CD47, CNDP2, COL5A2, GRINA, GSDMD, LGALS9 +9 moreView in SCUBA
EnterocytesIFN-gamma immunoproteasome
Inflammation
ABCC3, ACTR2, CARD16, DMBT1, GOLM1, IQGAP1, PSMB8, PSMB9 +2 moreView in SCUBA
FibroblastsNF-κB Inflammatory Activation
Inflammatory
BIRC3, CD40, DRAM1, HAPLN3, IL15RA, IL32, LAP3, STAT1 +5 moreView in SCUBA
Glial cellsNF-κB/IFN Inflammatory
Inflammation
BIRC3, CXCL10, CXCL2, CXCL9, FDCSP, HAPLN3, ICAM1, PTX3 +4 moreView in SCUBA
Goblet cellsMucosal Innate Defense
Immune function
BOLA3, DMBT1, ENO1, GPI, LGALS3BP, OLFM4, PIGR, PLA2G2A +4 moreView in SCUBA
Lymphatic endothelialHypoxia HIF Response
Stress
AKR1C1, AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CSRP2, EGLN3 +4 moreView in SCUBA
MacrophagesLysosomal Hydrolase Program
Lysosomal & pahgocytosis
AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 moreView in SCUBA
PericytesNF-κB Inflammatory Activation
Inflammatory
EFHD2, HIF1A, IL32, LAP3, OSMR, TAPBP, TMEM165View in SCUBA

About the gene

Chromosome1: 150730079-150765957
Predicted locationIntracellular
Essential geneNo
Protein classEnzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionHydrolase, Protease, Thiol protease

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.