CLEC2B — C-type lectin domain family 2 member B

CLEC2B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CLEC2B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NFkB/MAPK activation BCR/AP1/NFKb pathway	BIRC3, CCDC107, CD72, CHI3L2, DENND4A, LRRFIP1, MAP3K8, MYADM +7 more	View in SCUBA
CD4⁺ T cells	Integrin Adhesion Migration migration & adhesion	ARAP2, ATF7IP, C4orf3, COTL1, CTSH, DEK, DIAPH1, EML4 +11 more	View in SCUBA
Fibroblasts	Interferon Response Inflammatory	A4GALT, ABCA1, ABHD17C, BASP1, CCL7, IFI16, IFI6, PLSCR1 +5 more	View in SCUBA
Gamma-delta T cells	Transcriptional Repressor Complex DNA/chromatin regulation	BAG1, CAB39, EBP, FBXO31, GFI1, MAN1A1, MAP2K1, MFSD6 +14 more
Innate lymphoid cells	NK Receptor Signaling Cytotoxicity	B2M, CD48, DCK, FCER1G, FKBP11, GPR108, HLA-A, HLA-B +12 more	View in SCUBA
Macrophages	Lysosomal Hydrolase Program Lysosomal & pahgocytosis	AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, COMT, CTSS +35 more	View in SCUBA
Monocytes	Inflammatory Monocyte Activation Inflammatory	ALDOA, C11orf98, CNIH4, CRIP1, GRINA, IFITM2, LEPROTL1, NBPF26 +5 more	View in SCUBA

About the gene

Synonyms	AICL, CLECSF2, HP10085
Chromosome	12: 9852369-9869386
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK- cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.