ARMH4 — Armadillo like helical domain containing 4
ARMH4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARMH4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | AMD1, AQP7, CDC14B, FBXO34, GATA2, GLUL, KLF3, MTURN +7 more | View in SCUBA |
About the gene
| Synonyms | C14orf37, UT2 |
|---|---|
| Chromosome | 14: 57999735-58298139 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
May modulate immune response and may play a role in inflammation. Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at 'Tyr-705'. May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.