Endothelial Quiescence
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes GATA2 (endothelial transcription factor), GLUL (venous/homeostatic EC marker), TIMP3 (ECM homeostasis, vascular quiescence), KLF3 (quiescence-associated Krüppel-like factor), and RUNX1T1 (transcriptional repressor of activation) collectively define a quiescent/homeostatic endothelial program. The module is significantly downregulated in UC inflammation and upregulated in remission, consistent with loss of endothelial homeostasis during active disease and its restoration upon remission. NDRG4, AMD1, and CDC14B support a non-proliferative, metabolically stable state. Neighbor M92 similarly shows remission upregulation with arterial identity genes, supporting that both modules reflect complementary homeostatic EC programs suppressed by inflammation.
Genes
AMD1, AQP7, ARMH4, CDC14B, FBXO34, GATA2, GLUL, KLF3, MTURN, NDRG4, NTHL1, PRICKLE2, RUNX1T1, SPATA13, SSUH2, TIMP3
Most correlated modules
- EC Inflammatory Activation · correlation 0.83
- Arterial EC Identity · correlation 0.83
- Arterial EC Identity · correlation 0.83
- Vascular Homeostasis · correlation 0.82
- EC Barrier Integrity · correlation 0.79
- Cytoskeletal Scaffolding · correlation 0.78
- Inflammatory Angiogenic Activation · correlation 0.72
- EC Quiescence Identity · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.