FBXO34 — F-box protein 34
FBXO34 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBXO34's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, CENPC, DEAF1, HAX1, HECTD1, KMT5C, MRPL50, NDUFA5 +7 more | View in SCUBA |
| Endothelial | Endothelial Quiescence Endothelial cell development | AMD1, AQP7, ARMH4, CDC14B, GATA2, GLUL, KLF3, MTURN +7 more | View in SCUBA |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FGD6, GUCY1A1, ITGA6, MDFIC, NAV1 +13 more | View in SCUBA |
| Macrophages | Chromatin Epigenetic Regulation Housekeeping | ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2 +21 more | View in SCUBA |
About the gene
| Synonyms | Fbx34, FLJ20725 |
|---|---|
| Chromosome | 14: 55271344-55370053 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.