SCUBA

KLF3 — KLF transcription factor 3

KLF3 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KLF3's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsTGF-beta/differentiation
Intercellular communication
CDC42SE1, CEMIP2, ENC1, LYST, SLC12A6, SMAD3, ST3GAL1, TSPAN3View in SCUBA
CD4⁺ T cellsNaive T quiescence
T cell development
CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, NOSIP, RASA3 +6 moreView in SCUBA
CD8⁺ T cellsNaive/Central Memory
T cell maturation
AIF1, ATM, CCR7, FCMR, FOXP1, KLF2, LDLRAP1, LEF1 +7 moreView in SCUBA
EndothelialEndothelial Quiescence
Endothelial cell development
AMD1, AQP7, ARMH4, CDC14B, FBXO34, GATA2, GLUL, MTURN +7 moreView in SCUBA
Gamma-delta T cellsNaive T cell quiescence
T cell maturation
ADAP1, ARL4C, BCL9L, BMAL1, CALM1, CAMK1D, CD44, CD5 +10 more
Goblet cellsGoblet Cell Differentiation
Epithelial development
CLDN4, EIF1, ELF3, KLF4, MIDN, PPP1R15A, RAB11FIP1, TOB1View in SCUBA
Innate lymphoid cellsNK Homing Circulating
Homing & TEM
ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 moreView in SCUBA
MacrophagesMyeloid Signaling Regulation
Innate immunity
ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 moreView in SCUBA
Mucosal-associated invariant T cellChromatin Regulation
DNA/chromatin regulation
ATF7IP2, CHD6, LYST, NLRP1, OSBPL8, P2RY8, SF3B6, SNU13 +1 more
PericytesRAS Cytoskeletal Signaling
Cytoskeletal
ARPC5L, CNDP2, FAM177A1, KRAS, LRRFIP1, PEA15, PTPN12, UBE2J1View in SCUBA

About the gene

SynonymsBKLF
Chromosome4: 38664197-38701517
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins, Transcription factors
Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Function

Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.