MTURN — Maturin, neural progenitor differentiation regulator homolog
MTURN belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTURN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | AMD1, AQP7, ARMH4, CDC14B, FBXO34, GATA2, GLUL, KLF3 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Cytoskeletal Remodeling Cytoskeletal | AHNAK, ANXA1, ATP2B1, DPYSL3, FHL1, IDS, MBOAT7, PBXIP1 +5 more |
About the gene
| Synonyms | C7orf41, Ells1, FLJ25903 |
|---|---|
| Chromosome | 7: 30134986-30162762 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
Function
Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression. Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536'. May be involved in early neuronal development (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.