GATA2 — GATA binding protein 2
GATA2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GATA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | AMD1, AQP7, ARMH4, CDC14B, FBXO34, GLUL, KLF3, MTURN +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Progenitor Granulocyte development | CD84, CPA3, FRY, HPGDS, IKZF2, NLK, REXO5, RRBP1 +2 more | |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | CCN1, CCN2, DUSP2, FOXC1, GADD45B, GADD45G, HES5, HSPA2 +9 more | View in SCUBA |
| Pericytes | Arterial Identity TFs Developmental | EPHA4, FLNB, MAST4, MECOM, MTUS1, PALMD, PIK3C2B, SOX17 | View in SCUBA |
About the gene
| Synonyms | NFE1B |
|---|---|
| Chromosome | 3: 128479427-128493201 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Phagocytosis, Transcription, Transcription regulation |
Function
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'- AGATAG-3'
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.