AXIN1 — Axin 1
AXIN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AXIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Terminal T Differentiation T cell maturation | B3GAT1, C1orf174, CEBPA, ENC1, F2R, GLUL, GTF3C1, IGF2R +10 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | ENC1, FAM53B, GTF3C1, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2, LAIR2 +3 more | View in SCUBA |
About the gene
| Synonyms | PPP1R49 |
|---|---|
| Chromosome | 16: 287440-352723 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Apoptosis, Wnt signaling pathway |
Function
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also a component of the AXIN1- HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.