KIR3DL2 — Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2
KIR3DL2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIR3DL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1 +14 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | AXIN1, ENC1, FAM53B, GTF3C1, KIR2DL1, KIR2DL3, KIR3DL1, LAIR2 +3 more | View in SCUBA |
About the gene
| Synonyms | CD158K, cl-5, nkat4, nkat4a, nkat4b |
|---|---|
| Chromosome | 19: 54850443-54867207 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.