Terminal T Differentiation
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
B3GAT1 (CD57) is a canonical marker of terminally differentiated/senescent T and NK cells with high PageRank. F2R, PTPRE, and ST3GAL4 reflect surface remodeling in late-stage effectors. OASL indicates antiviral effector activity. TFDP2 and GTF3C1 may reflect transcriptional rewiring in terminal differentiation. GLUL and AXIN1 suggest metabolic/signaling adaptations. The strong coherence and neighbor context (adjacent to cytotoxic M155 and M20) support a terminal differentiation program marked by CD57.
Genes
AXIN1, B3GAT1, C1orf174, CEBPA, ENC1, F2R, GLUL, GTF3C1, IGF2R, LGR6, MTMR12, OASL, OSBPL5, PTPRE, RAB11FIP5, SLC15A4, ST3GAL4, TFDP2, TMEM273
Most correlated modules
- Innate Stress Signaling · correlation 0.82
- NK-like Terminal Differentiation · correlation 0.81
- Cytotoxic Effector Program · correlation 0.81
- Cytotoxic Effector Program · correlation 0.80
- Tissue-resident gd T · correlation 0.70
- TCR Activation Signaling · correlation 0.70
- TGF-β Migration Program · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.