KIR2DL3 — Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
KIR2DL3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIR2DL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1 +14 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | AXIN1, ENC1, FAM53B, GTF3C1, KIR2DL1, KIR3DL1, KIR3DL2, LAIR2 +3 more | View in SCUBA |
About the gene
| Synonyms | CD158B2, cl-6, nkat2, nkat2a, nkat2b, p58 |
|---|---|
| Chromosome | 19: 54738513-54753052 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor on natural killer (NK) cells for HLA-C alleles (HLA- Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.