ENC1 — Ectodermal-neural cortex 1
ENC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TGF-beta/differentiation Intercellular communication | CDC42SE1, CEMIP2, KLF3, LYST, SLC12A6, SMAD3, ST3GAL1, TSPAN3 | View in SCUBA |
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| Gamma-delta T cells | Terminal T Differentiation T cell maturation | AXIN1, B3GAT1, C1orf174, CEBPA, F2R, GLUL, GTF3C1, IGF2R +10 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | AXIN1, FAM53B, GTF3C1, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2, LAIR2 +3 more | View in SCUBA |
About the gene
| Synonyms | ENC-1, KLHL37, NRPB, PIG10, TP53I10 |
|---|---|
| Chromosome | 5: 74627406-74641424 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Developmental protein |
Function
Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down- regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.