KIR2DL1 — Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
KIR2DL1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIR2DL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL3 +14 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | AXIN1, ENC1, FAM53B, GTF3C1, KIR2DL3, KIR3DL1, KIR3DL2, LAIR2 +3 more | View in SCUBA |
About the gene
| Synonyms | 47.11, CD158A, cl-42, nkat1, p58.1 |
|---|---|
| Chromosome | 19: 54769793-54784322 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.