GTF3C1 — General transcription factor IIIC subunit 1
GTF3C1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF3C1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Terminal T Differentiation T cell maturation | AXIN1, B3GAT1, C1orf174, CEBPA, ENC1, F2R, GLUL, IGF2R +10 more | |
| Mucosal-associated invariant T cell | NF-κB Activation Immune regulation | BCL3, FURIN, IRAK1, IRS2, ISCA1, PITHD1, PRELID3B, RABGGTB +3 more | |
| Natural Killer cells | KIR+ NK Maturation Immune regulation | AXIN1, ENC1, FAM53B, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2, LAIR2 +3 more | View in SCUBA |
About the gene
| Synonyms | TFIIIC220 |
|---|---|
| Chromosome | 16: 27459555-27549913 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription |
Function
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.