BARD1 — BRCA1 associated RING domain 1
BARD1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BARD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BRCA1, CENPK, CENPM, CENPU, CLSPN, DHFR +31 more | View in SCUBA |
About the gene
| Chromosome | 2: 214725646-214809683 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.