S-phase DNA Replication
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 40 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 19 of 40 genes have a known function matching the annotation |
Why this annotation
MCM7 and MCM4 are replicative helicase subunits (MCM complex) marking S-phase entry. TYMS (thymidylate synthase) and DHFR (dihydrofolate reductase) are rate-limiting enzymes for dTMP synthesis, classic S-phase markers. RRM1 encodes ribonucleotide reductase. FEN1 processes Okazaki fragments. CLSPN is the replication checkpoint mediator (claspin). PCLAF (PCNA-associated factor) and HELLS are S-phase chromatin factors. BRCA1, MAD2L1, ZWINT, CENPU, CENPK are DNA damage/kinetochore checkpoint proteins. ATAD2 is a chromatin remodeler in S-phase. This is a canonical S-phase/DNA replication module with extremely high prolif_mac enrichment (TYMS 133x, PCLAF 71x).
Genes
ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN, DHFR, DNAJC9, DUT, FAM111B, FEN1, GGH, GMNN, HELLS, LMNB1, MAD2L1, MCM3, MCM4, MCM5, MCM6, MCM7, ORC6, PCLAF, PCNA, PHF19, RAD51AP1, RFC4, RRM1, RRM2, SHCBP1, SMC2, SVIP, TCF19, TK1, TMEM106C, TYMS, UBE2T, ZWINT
Most correlated modules
- Mitotic Chromosome Condensation · correlation 0.91
- Mitotic Spindle Assembly · correlation 0.84
- DNA Replication Metabolism · correlation 0.82
- G1/S Transition · correlation 0.82
- Mitotic Spindle · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.