CENPM — Centromere protein M
CENPM belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle G1/S Cell cycle | CARHSP1, CBX5, DNMT1, GMNN, HMGB2, HMGN2, MND1, MYBL2 +8 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF, RRM1 +5 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPU, CLSPN, DHFR +13 more | |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, BRCA2, CLSPN, DNAJC9, FANCI, LIG1, PKMYT1, RRM1 | View in SCUBA |
| Hematopoietic progenitor cells | Late S-phase G2 Entry Cell cycle | ASF1B, CDC45, CDCA5, DIAPH3, MND1, MYBL2, PKMYT1, RAD51AP1 +1 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPU, CLSPN, DHFR +31 more | View in SCUBA |
| Natural Killer cells | S-phase Replication Cell cycle | CDT1, CENPU, CLSPN, FANCI, PCLAF, RRM2, TYMS | View in SCUBA |
About the gene
| Synonyms | C22orf18, CENP-M, MGC861, Pane1 |
|---|---|
| Chromosome | 22: 41938737-41947152 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.