CENPU — Centromere protein U
CENPU belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPU's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | ASF1B, CDC6, CDCA5, CDT1, CENPK, CLSPN, DNAJC9, FAM111B +5 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF, RRM1 +5 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA1, BRCA2, CENPH, CENPK, DHFR, EZH2 +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CLSPN, DHFR +13 more | |
| Goblet cells | S-phase DNA Replication Cell cycle | ASF1B, BRCA1, CDC6, DHFR, FEN1, MYBL2, PCLAF, TK1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Replication Stress Response Cell cycle | DNAJC9, EIF2AK1, HLTF, MRPL52, PIP4K2A, POLE2, SLC12A6, TLN1 +2 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CLSPN, DHFR +31 more | View in SCUBA |
| Natural Killer cells | S-phase Replication Cell cycle | CDT1, CENPM, CLSPN, FANCI, PCLAF, RRM2, TYMS | View in SCUBA |
About the gene
| Synonyms | CENP-50, CENP-U, KLIP1, MLF1IP, PBIP1 |
|---|---|
| Chromosome | 4: 184694085-184734130 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.