CLSPN — Claspin
CLSPN belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLSPN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | ASF1B, CDC6, CDCA5, CDT1, CENPK, CENPU, DNAJC9, FAM111B +5 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, DHFR +13 more | |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, BRCA2, CENPM, DNAJC9, FANCI, LIG1, PKMYT1, RRM1 | View in SCUBA |
| Hematopoietic progenitor cells | Replication Origin Licensing Cell cycle | BRCA1, CDC6, DTL, FAM111B, MCM10, ORC6, WDR76, XRCC2 | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, DHFR +31 more | View in SCUBA |
| Natural Killer cells | S-phase Replication Cell cycle | CDT1, CENPM, CENPU, FANCI, PCLAF, RRM2, TYMS | View in SCUBA |
About the gene
| Chromosome | 1: 35720218-35769978 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, DNA damage, DNA repair |
Function
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.