BLOC1S6 — Biogenesis of lysosomal organelles complex 1 subunit 6
BLOC1S6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BLOC1S6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | NF-κB Activation Inflammatory | BCL3, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD, DNAJB6 +33 more | View in SCUBA |
About the gene
| Synonyms | HPS9, PA, PLDN |
|---|---|
| Chromosome | 15: 45587214-45615945 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.