NF-κB Activation
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 42 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 42 genes have a known function matching the annotation |
Why this annotation
Hub genes REL (NF-κB subunit), CYLD (NF-κB deubiquitinase), NFKBID (IκB family member), ICAM1, CD83, CFLAR are all canonical NF-κB pathway components or transcriptional targets. MAFF and NFE2L2 add oxidative stress/Nrf2 co-regulation. KDM6B epigenetically licenses inflammatory gene expression. ETV3 and CSRNP1 are transcriptional repressors that modulate NF-κB output. The module reflects NF-κB activation with built-in negative feedback, consistent with macrophage inflammatory activation in the gut. Mild mono_mac enrichment for several genes supports macrophage-specific activation.
Genes
BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD, DNAJB6, DUSP5, EDEM1, ETV3, ICAM1, ICOSLG, IFNAR2, KDM6B, KLC1, KLHL15, MAFF, MAP3K11, MIDEAS, NFE2L2, NFKB2, NFKBID, NR4A3, NSUN6, PPP1R15B, PRDM1, PRMT9, PTPRE, PURB, RASGEF1B, REL, SAMD4B, SELENOK, SKIL, SLC25A44, TNFAIP2, ZBTB1, ZBTB10, ZC3H12A, ZNF331
Most correlated modules
- Splicing Factor Regulation · correlation 0.92
- Macrophage Lipid Sensing · correlation 0.92
- Early response genes · correlation 0.91
- Anti-inflammatory Response · correlation 0.91
- Mixed Regulatory Signaling · correlation 0.89
- Stress Response Transcription · correlation 0.87
- JAK-STAT Cytokine Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.