DNAJB6 — DnaJ heat shock protein family (Hsp40) member B6

DNAJB6 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DNAJB6's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, EIF5 +13 more	View in SCUBA
CD4⁺ T cells	Heat-shock response Stress	AHSA1, BAG3, CACYBP, CCDC117, DYNLL1, FKBP4, GADD45G, HSPA6 +5 more	View in SCUBA
CD8⁺ T cells	Autophagy Metabolic Stress Stress	CREM, CTSC, DOK2, EFHD2, GNG2, ICOS, MAP1LC3B, NDUFC1 +2 more	View in SCUBA
Fibroblasts	Integrated Stress Response Stress	ATF4, BAIAP2, EIF4A3, EIF5, FSCN1, HSP90AB1, HSPD1, HSPE1 +9 more	View in SCUBA
Gamma-delta T cells	Stress Negative Feedback Immune regulation	ANKRD12, AZIN1, CCDC186, CDKN1A, CYLD, DENND4A, DUSP10, ELL +7 more
Glial cells	Proteostasis Stress Response Stress	EIF5, HNRNPA0, NUDT4, RSRC2, SQSTM1, TRIM8, UBE2D3, ZC3HAV1	View in SCUBA
Goblet cells	mRNA Stability Control RNA processing & translation	BTG1, PNRC1, SRSF5, TENT5C, TSC22D1, TUBA1A, TXNIP, UBXN1 +5 more	View in SCUBA
Innate lymphoid cells	Integrated Stress Response Stress	AMD1, ATF4, CYCS, DDX5, EIF1, GPBP1, HERPUD1, HNRNPH1 +3 more	View in SCUBA
Lymphatic endothelial	Heat Shock Chaperone Stress	AHSA1, CCT4, CHORDC1, FKBP4, HSPD1, STIP1, TCP1	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Mucosal-associated invariant T cell	Splicing Regulation RNA processing & translation	AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, IL23R, NEU1 +9 more
Natural Killer cells	ER Stress Response Stress	ARF4, CYCS, EIF4A3, EIF5, GADD45B, HERPUD1, SAP18, SERTAD1	View in SCUBA
Pericytes	Proteostasis Quality Control Housekeeping	GNAI3, HNRNPF, HSP90AB1, HSPE1, MAP1LC3B, MRPL18, UBE2D3	View in SCUBA

About the gene

Synonyms	LGMD1D, MRJ
Chromosome	7: 157335381-157417439
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins
Molecular function	Chaperone

Function

Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co- chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine- containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity. Isoform B but not isoform A inhibits huntingtin aggregation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.