C5AR1 — Complement C5a receptor 1
C5AR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C5AR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, CAB39 +33 more | View in SCUBA |
| Monocytes | Complement Receptor Activation Lysosomal & pahgocytosis | AVPI1, C5AR2, CLEC7A, CSF2RA, MAT2A, METRNL, PTPRE, RAB20 +1 more | View in SCUBA |
| Neutrophils | C5aR Complement Activation Innate immunity | ADGRG3, CD55, ITPRIP, LAPTM5, MCL1, PFKFB3, PTPRE, RYBP +3 more |
About the gene
| Synonyms | C5A, C5AR, C5R1, CD88 |
|---|---|
| Chromosome | 19: 47290023-47322066 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Chemotaxis |
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high- affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.