ADAM9 — ADAM metallopeptidase domain 9
ADAM9 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAM9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CALU, CLMP, CNN3, GLIPR1, ITGAV, MCRIP1, NAP1L1, PRNP +5 more | View in SCUBA |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ALCAM, ANO6, B3GNT2, BTG1, C5AR1, CAB39 +33 more | View in SCUBA |
About the gene
| Synonyms | CORD9, KIAA0021, MCMP, MDC9, Mltng |
|---|---|
| Chromosome | 8: 38996754-39105445 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell- matrix interactions and regulate the motility of cells via interactions with integrins. May act as alpha-secretase for amyloid precursor protein (APP)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.