B3GNT2 — UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
B3GNT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2, EVI5 +23 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing & Trafficking RNA processing & translation | ARF1, ARL6IP1, ARRDC2, C17orf49, CCDC12, CWC15, DDX39A, EIF5A +19 more | |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, BTG1, C5AR1, CAB39 +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | Autophagy & Trafficking Stress | ATG2A, BEST1, CEBPZ, CTPS1, ELOA, KANSL2, LITAF, MTFP1 +6 more |
About the gene
| Synonyms | B3GN-T1, B3GN-T2, B3GNT-2, B3GNT1, BETA3GNT |
|---|---|
| Chromosome | 2: 62196115-62224731 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors. Probably constitutes the main polylactosamine synthase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.