ANO6 — Anoctamin 6
ANO6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANO6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Cytoskeletal Scaffolding Cytoskeletal | ADD1, AGPAT1, ARL6IP5, CDC42BPA, CHURC1, DOCK1, ERC1, MAP4 +6 more | View in SCUBA |
| Enterocytes | Mature enterocyte transport Absorption | ABCG8, ANXA13, KAZN, PIK3C2G, RASGEF1B, SLC16A10, TCEA3, TLN2 +1 more | View in SCUBA |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, B3GNT2, BTG1, C5AR1, CAB39 +33 more | View in SCUBA |
About the gene
| Synonyms | DKFZp313M0720, TMEM16F |
|---|---|
| Chromosome | 12: 45215987-45482280 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Chloride channel, Ion channel, Voltage-gated channel |
| Biological process | Host-virus interaction, Ion transport, Lipid transport, Transport |
Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity). (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.