Hypoxia-driven Activation
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 42 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 42 genes have a known function matching the annotation |
Why this annotation
HIF1A is the master transcriptional regulator of hypoxia response and is the top functional hub. C5AR1 (complement receptor 5a, 5.7x enriched in mono_mac) drives macrophage inflammatory activation. NCOA4 mediates ferritinophagy under iron/hypoxic stress. ADAM9 and ADAM10 are metalloprotease sheddases upregulated by HIF1A and involved in inflammatory ectodomain shedding. BTG1 is an anti-proliferative gene induced under stress. MARCKS is a PKC substrate involved in macrophage inflammatory signaling. NPC1 handles lysosomal cholesterol trafficking. CYFIP1 and CORO1C regulate actin dynamics downstream of Rac1. The convergence of HIF1A, complement receptor C5AR1, and metalloprotease activity strongly supports a hypoxia-driven inflammatory macrophage activation program.
Genes
ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1, CAB39, CD58, CORO1C, CYFIP1, FNDC3B, GTF2I, HIF1A, HPCAL1, HS2ST1, ITPRIP, KCNAB2, LHFPL2, LIX1L, MARCKS, ME2, MLLT1, MLLT6, MROH1, MXD1, NCOA4, NPC1, NPTN, PLAUR, PLBD2, PLEC, PLK3, SLC12A6, SLC2A3, SNRPN, SPPL2A, SPTLC1, SRSF8, TXNIP, ZDHHC20
Most correlated modules
- Monocyte-Mac Iron Transport · correlation 0.94
- Endolysosomal Trafficking · correlation 0.94
- Phagocytic Endolysosomal · correlation 0.93
- Alternative Activation Lipid · correlation 0.90
- Inflammatory Monocyte Activation · correlation 0.89
- RNA Processing Housekeeping · correlation 0.89
- Transcriptional Regulation · correlation 0.88
- Monocyte Innate Signaling · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.