CCL23 — C-C motif chemokine ligand 23
CCL23 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL23's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CH25H, CSRP2, CTSC, DENND2D, DRAM2 +20 more | View in SCUBA |
About the gene
| Synonyms | Ckb-8, CKb8, MIP-3, MPIF-1, SCYA23 |
|---|---|
| Chromosome | 17: 36013056-36017972 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Heparin-binding |
| Biological process | Chemotaxis, Inflammatory response |
Function
Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.