CARMIL1 — Capping protein regulator and myosin 1 linker 1
CARMIL1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CARMIL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CCL23, CH25H, CSRP2, CTSC, DENND2D, DRAM2 +20 more | View in SCUBA |
| Enterocytes | Focal adhesion actin Migration & adhesion | BAZ2B, COP1, FRYL, KIF13A, LPP, MYO6, PALLD, PTK2 +4 more | View in SCUBA |
About the gene
| Synonyms | CARMIL, dJ501N12.1, FLJ20048, LRRC16, LRRC16A |
|---|---|
| Chromosome | 6: 25279078-25620530 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.