SCUBA

DENND2D — DENN domain containing 2D

DENND2D belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DENND2D's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsChromatin Regulation
DNA/chromatin regulation
ADI1, ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DNTTIP2 +17 moreView in SCUBA
CD8⁺ T cellsEffector Memory CD8
T cell maturation
CLDND1, GIMAP1, GIMAP4, GIMAP7, GPR183, GZMK, ITM2C, KLRG1 +3 moreView in SCUBA
EndothelialMyeloid Contamination
Cell contamination
BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DRAM2 +20 moreView in SCUBA
Gamma-delta T cellsT cell Survival
T cell maturation
ARFRP1, BCL2L1, C6orf47, CHD9, DAXX, DEF6, DHPS, ERGIC2 +26 more
Innate lymphoid cellsJAK-STAT Cytokine Signaling
Inflammation
AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, EDEM2, EIF4EBP2 +23 moreView in SCUBA
MacrophagesOxidative Metabolic Program
Mitochondrial & OxPhos
ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, EIF4EBP1 +29 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial Biogenesis
Mitochondrial & OxPhos
ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, COA4, DBP, DMAC1 +15 more
Natural Killer cellsNK Lymphocyte Survival
Immune regulation
FGR, GIMAP1, GIMAP4, GIMAP7, IL16, PTGDR, SLAMF6, TRAF3IP3View in SCUBA

About the gene

SynonymsFLJ22457, RP5-1180E21.2
Chromosome1: 111185969-111204535
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionGuanine-nucleotide releasing factor

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.