CSRP2 — Cysteine and glycine rich protein 2
CSRP2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSRP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CTSC, DENND2D, DRAM2 +20 more | View in SCUBA |
| Fibroblasts | ICC electrophysiological machinery Gut motility | ADRB3, CAP2, CDCA7L, DTNA, GREM2, LGI1, LMO3, MEF2C +5 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia HIF Response Stress | AKR1C1, AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CTSS, EGLN3 +4 more | View in SCUBA |
| Pericytes | Pericyte ECM Secretion ECM production | ATP1A2, CPM, DACH1, EFEMP1, FRZB, GULP1, MASP1, NDUFAF4 +3 more | View in SCUBA |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ARHGAP29, ATP10A, BBX, CDK18, EDNRA, GPAT2, NR3C1, NUDT4 +4 more | View in SCUBA |
About the gene
| Synonyms | CRP2, LMO5, SmLIM |
|---|---|
| Chromosome | 12: 76858709-76879023 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation |
Function
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.