Myeloid Contamination
Gene co-expression module in Endothelial
| Category | Cell contamination |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
This module contains multiple canonical myeloid/immune markers: ITGAM (CD11b, myeloid integrin), SLAMF1 (immune signaling receptor), IL2RG (common gamma chain of cytokine receptors), TMEM176A/B (myeloid/DC-associated ion channels), CTSC (cathepsin C, myeloid protease). Additional genes include PTGES/PTGDS (prostaglandin synthesis, inflammatory), C7 (complement), THY1 (stromal/fibroblast marker), MEOX2 (vascular TF), CSRP2 (smooth muscle/fibroblast). The strong UC inflammation signal and myeloid gene enrichment suggest this module reflects myeloid cell contamination or co-clustering with endothelial cells in inflamed tissue. HDAC9 and BASP1 add transcriptional regulation context. The mixed immune/stromal composition and uniform subset expression support contamination.
Genes
BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D, DRAM2, ENPP6, GUCY1B1, HDAC9, HSPB8, IL2RG, ITGAM, MEOX2, PLGRKT, PTGDS, PTGES, RGS10, RIOX2, SDR16C5, SLAMF1, SPNS3, SYT15, TACR1, THY1, TMEM176A, TMEM176B
Most correlated modules
- Leukocyte Recruitment Signaling · correlation 0.87
- IL33 Alarmin Signaling · correlation 0.82
- Immune Cell Contamination · correlation 0.81
- Lysosomal Autophagy Program · correlation 0.78
- Arterial EC Identity · correlation 0.74
- Angiogenic Metabolic Adaptation · correlation 0.73
- Venular Inflammatory Activation · correlation 0.73
- Inflammatory Stress Response · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.