CD19 — CD19 molecule
CD19 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD19's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation B cell maturation | ADAM19, ARHGAP30, CD164, CD47, CLN8, CPEB4, ELK3, FNIP1 +15 more | View in SCUBA |
About the gene
| Chromosome | 16: 28931965-28939342 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.