B-cell activation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
This strong module is rich in B-cell identity and surface/signaling genes: CD19 (canonical B marker), POU2F2 (Oct2, B-cell TF), CD164, CD47, TSPAN33, ADAM19, plus immune signaling IFNGR1, ITGB2, ARHGAP30. The combination of B-cell lineage TFs (POU2F2), CD19, and surface receptors marks a B-cell activation/identity program. Disease-associated (sig in UC and CD inflammation), consistent with activated B-cell state.
Genes
ADAM19, ARHGAP30, CD164, CD19, CD47, CLN8, CPEB4, ELK3, FNIP1, IFNGR1, ITGB2, LRP10, MEF2A, POU2F2, RASSF2, RHOQ, SH3BP5, SIPA1L1, SLC38A1, SLC4A7, TLN1, TPP1, TSPAN33, WDFY4
Most correlated modules
- Atypical memory B cell · correlation 0.87
- B-cell signaling regulators · correlation 0.82
- ER/vesicle trafficking · correlation 0.81
- B-cell antigen presentation · correlation 0.81
- B cell activation · correlation 0.81
- B Cell Identity Signaling · correlation 0.80
- Lymphoid signaling regulators · correlation 0.78
- BCR Signaling Regulation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.