ELK3 — ETS transcription factor ELK3
ELK3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation B cell maturation | ADAM19, ARHGAP30, CD164, CD19, CD47, CLN8, CPEB4, FNIP1 +15 more | View in SCUBA |
| Fibroblasts | OSM Cytokine Response Inflammatory | ARID5B, FGF7, OSMR, PDE4B, PTGER1, RNF145, UFM1 | View in SCUBA |
| Hematopoietic progenitor cells | Megakaryocyte IFN-primed Inflammatory | COL24A1, GBP4, GUCY1A1, HLA-E, IFI16, IQGAP2, MAML2, MYO5C +2 more | |
| Innate lymphoid cells | IFN-gamma Response Inflammation | APOL6, B3GALT5, DST, GBP2, GBP4, GBP5, GOLGA8A, HLA-DRB1 +16 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELN, FLT4, KCNN3 +10 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
About the gene
| Synonyms | ERP, NET, SAP2 |
|---|---|
| Chromosome | 12: 96194375-96269824 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.