ADAM19 — ADAM metallopeptidase domain 19
ADAM19 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAM19's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation B cell maturation | ARHGAP30, CD164, CD19, CD47, CLN8, CPEB4, ELK3, FNIP1 +15 more | View in SCUBA |
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1, HIPK1 +23 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Effector Activation activation | ARHGEF3, BATF, CD151, CDK4, FES, FURIN, HLA-F, IL22 +16 more | View in SCUBA |
| Monocytes | Monocyte Chemokine Secretion Inflammatory | ACOD1, CCL2, CCL7, CLEC5A, CXCL11, GBP3, IL27 | View in SCUBA |
| Neutrophils | Inflammasome Signaling Regulation Inflammatory | F5, MAP2K6, NLRP12, PRKACA, RNF10, SLC37A3, TENM1 | |
| Smooth muscle cells | Matrix Crosslinking Activation ECM remodeling | COL23A1, FOXF1, LOXL2, NKX2-3, PLPP1, RCN1, VCAN | View in SCUBA |
About the gene
| Synonyms | MLTNB |
|---|---|
| Chromosome | 5: 157395534-157575775 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.