CD200R1 — CD200 receptor 1
CD200R1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD200R1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell co-receptors T cell development | AGO4, ARRB2, CAPG, CD40LG, CD96, EMB, FKBP11, GAB3 +13 more | View in SCUBA |
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CCND1, CFD, CR1, CTSF, EMB, EPHX1, F13A1 +16 more | View in SCUBA |
About the gene
| Synonyms | CD200R, HCRTR2, MOX2R, OX2R |
|---|---|
| Chromosome | 3: 112921205-112975103 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Host-virus interaction |
Function
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro- inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.