ACVRL1 — Activin A receptor like type 1
ACVRL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACVRL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ANXA11, ATP13A2, ENG, HPCAL1, HYAL1, LDB2, MACF1, NFIB +7 more | View in SCUBA |
| Fibroblasts | BMP-ECM Fibroblast ECM remodeling | CLEC11A, GNG11, ITGB5, LAMA2, MRC2, TFPI, VCAN | View in SCUBA |
| Macrophages | Resident Mac Identity Tissue homeostasis | CCND1, CD200R1, CFD, CR1, CTSF, EMB, EPHX1, F13A1 +16 more | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL, MPZL2 +7 more | View in SCUBA |
About the gene
| Synonyms | ACVRLK1, ALK1, HHT, HHT2, ORW2 |
|---|---|
| Chromosome | 12: 51906908-51923361 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
| Biological process | Angiogenesis |
Function
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.