EPHX1 — Epoxide hydrolase 1
EPHX1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPHX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CAVIN2, CEACAM1, CYBA, DNMBP, EFCC1, GMFG, HID1, KANK3 +7 more | View in SCUBA |
| Fibroblasts | Microfibril ECM Fibroblast ECM production | CD302, CD81, COX7C, CYBRD1, MFAP4, NFIX, NOP53, NUCKS1 +2 more | View in SCUBA |
| Lymphatic endothelial | Caveolae Cytoskeletal Cytoskeletal | CALM1, CAVIN1, CRIP2, CTSZ, DYNLL1, GSTK1, HOXD8, HOXD9 +7 more | View in SCUBA |
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CCND1, CD200R1, CFD, CR1, CTSF, EMB, F13A1 +16 more | View in SCUBA |
| Smooth muscle cells | Activated Myofibroblast Activation | CNN3, IFI16, IGFBP4, LAPTM4B, NNMT, SERPING1, SSR4, SULF1 +3 more | View in SCUBA |
About the gene
| Synonyms | EPHX |
|---|---|
| Chromosome | 1: 225810124-225845563 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Aromatic hydrocarbons catabolism, Detoxification, Lipid metabolism |
Function
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.