Resident Mac Identity
Gene co-expression module in Macrophages
| Category | Tissue homeostasis |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 25 genes have a known function matching the annotation |
Why this annotation
FOLR2 and LYVE1 are canonical tissue-resident macrophage markers (particularly intestinal/serosal res_mac). F13A1 (coagulation factor XIII A1) is a well-established tissue-resident macrophage marker. PLTP (phospholipid transfer protein) and EPHX1 (epoxide hydrolase) indicate lipid metabolism. SLC40A1 (ferroportin) marks iron-exporting macrophages. GAS6 supports efferocytosis. CD200R1 is an anti-inflammatory/homeostatic receptor. CFD (complement factor D) and CR1 indicate complement involvement. PLXDC1 and MAMDC2 are extracellular matrix/vascular-associated. CTSF is a lysosomal cathepsin. This module captures the tissue-resident macrophage homeostatic identity with lipid and iron handling.
Genes
ACVRL1, CCND1, CD200R1, CFD, CR1, CTSF, EMB, EPHX1, F13A1, FOLR2, GAS6, GYPC, IGFBP4, LYVE1, MAMDC2, MS4A4A, P2RY14, PLTP, PLXDC1, RAB3IL1, SCN1B, SLC18B1, SLC40A1, TLR5, VSIG4
Most correlated modules
- Macrophage Identity · correlation 0.76
- Resident Mac Niche · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.