CR1 — Complement C3b/C4b receptor 1 (Knops blood group)
CR1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CCND1, CD200R1, CFD, CTSF, EMB, EPHX1, F13A1 +16 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Identity Developmental | ALPL, CRISPLD2, IL4R, NIBAN1, PXN, SH3GLB1, ST3GAL4 |
About the gene
| Synonyms | CD35, KN |
|---|---|
| Chromosome | 1: 207496147-207641765 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, CD markers, Plasma proteins, Predicted membrane proteins |
| Molecular function | Blood group antigen, Host cell receptor for virus entry, Receptor |
| Biological process | Complement pathway, Host-virus interaction, Immunity, Innate immunity |
Function
Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. (Microbial infection) Acts as a receptor for Epstein-Barr virus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.