CD72 — CD72 molecule
CD72 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD72's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NFkB/MAPK activation BCR/AP1/NFKb pathway | BIRC3, CCDC107, CHI3L2, CLEC2B, DENND4A, LRRFIP1, MAP3K8, MYADM +7 more | View in SCUBA |
About the gene
| Synonyms | CD72b, LYB2 |
|---|---|
| Chromosome | 9: 35609982-35646810 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.