NFkB/MAPK activation
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Top hubs PTGER4, MAP3K8 (TPL2), BIRC3, LRRFIP1, SLAMF1, CD72 point to NF-kB/MAPK activation and inflammatory signaling. BIRC3 and MAP3K8 are canonical NF-kB pathway effectors; PTGER4 (prostaglandin EP4 receptor) and SLAMF1 are immune activation markers. Strong coherence, upregulated in inflamed CD, consistent with an activation-driven NFkB/AP1 program in B cells.
Genes
BIRC3, CCDC107, CD72, CHI3L2, CLEC2B, DENND4A, LRRFIP1, MAP3K8, MYADM, PDE4A, PTGER4, SHF, SLAMF1, SMAP2, SNX2, ZNF667
Most correlated modules
- TGF-beta/differentiation · correlation 0.77
- Notch signaling · correlation 0.72
- Immediate early response · correlation 0.70
- NF-kB activation/survival · correlation 0.67
- Plasma cell secretory · correlation 0.65
- Hypoxia/metabolic stress · correlation 0.65
- MHC-II antigen presentation · correlation 0.64
- Naive B cell · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.