DENND4A — DENN domain containing 4A
DENND4A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND4A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NFkB/MAPK activation BCR/AP1/NFKb pathway | BIRC3, CCDC107, CD72, CHI3L2, CLEC2B, LRRFIP1, MAP3K8, MYADM +7 more | View in SCUBA |
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, GNL3 +21 more | View in SCUBA |
| Gamma-delta T cells | Stress Negative Feedback Immune regulation | ANKRD12, AZIN1, CCDC186, CDKN1A, CYLD, DNAJB6, DUSP10, ELL +7 more | |
| Lymphatic endothelial | MAPK-ERK Signaling migration & adhesion | ARIH1, BRAF, CPNE8, ELF2, FBXO11, FNDC3B, GRB10, NT5C2 +6 more | View in SCUBA |
| Macrophages | Ubiquitin Proteasome Regulation Housekeeping | ARIH1, BTAF1, CLASP2, DYRK1A, FBXO11, FBXW7, GATAD2B, LMBR1 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT4 T cell Identity T cell maturation | ATF7IP, CAMK4, CBLB, CD96, CELF2, IKZF1, JMJD1C, PIP4K2A +7 more |
About the gene
| Synonyms | IRLB, MYCPBP |
|---|---|
| Chromosome | 15: 65658046-65792293 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Guanine-nucleotide releasing factor |
| Biological process | Transcription, Transcription regulation |
Function
Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.