CHST2 — Carbohydrate sulfotransferase 2
CHST2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHST2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Natural Killer cells | NK Homing Adhesion Homing & TEM | IGFBP7, ITGAM, LAIR1, MLC1, MYOM2, NCR3, SPN | View in SCUBA |
About the gene
| Synonyms | C6ST |
|---|---|
| Chromosome | 3: 143119771-143124014 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Carbohydrate metabolism, Inflammatory response |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.