ITGAM — Integrin subunit alpha M
ITGAM belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGAM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, MCOLN2 +12 more | View in SCUBA |
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Gamma-delta T cells | γδ T Cell Identity T cell maturation | AGAP1, AGPAT4, C1orf21, CD226, CD47, GAS7, ITGA5, MYO1G +7 more | |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Monocytes | Myeloid Activation Innate immunity | CCDC88B, GAS7, IL17RA, LTB4R, PRAM1, PSTPIP1, TMEM91 | View in SCUBA |
| Natural Killer cells | NK Homing Adhesion Homing & TEM | CHST2, IGFBP7, LAIR1, MLC1, MYOM2, NCR3, SPN | View in SCUBA |
| Neutrophils | NET Priming State Netosis | ADD3, APMAP, ARG1, CCDC125, CCPG1, PADI4, PLBD1, PPP2R5A +1 more |
About the gene
| Synonyms | CD11B, CR3A, MAC-1 |
|---|---|
| Chromosome | 16: 31259967-31332892 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion, Immunity, Innate immunity |
Function
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.