NK Homing Adhesion
Gene co-expression module in Natural Killer cells
| Category | Homing & TEM |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
CHST2 encodes a sulfotransferase that generates 6-sulfo sialyl Lewis X on PSGL-1/CD43, creating functional L-selectin and P-selectin ligands critical for NK cell homing and rolling on endothelium. SPN (CD43) is the scaffold for these homing ligands. ITGAM (CD11b) marks mature NK cells and mediates adhesion. NCR3 (NKp30) is a key activating NK receptor. LAIR1 is an inhibitory collagen receptor on NK cells. IGFBP7 is associated with tissue residency and vascular contexts. Module is strongly upregulated in inflammation and reduced in remission, consistent with homing-competent mature NK cells recruited during intestinal inflammation.
Genes
CHST2, IGFBP7, ITGAM, LAIR1, MLC1, MYOM2, NCR3, SPN
Most correlated modules
- Cytotoxic NK Maturation · correlation 0.86
- Granulysin Cytotoxic Effector · correlation 0.83
- NK Homing & Residency · correlation 0.80
- Innate Sensing NK Regulation · correlation 0.77
- NK Degranulation Activation · correlation 0.76
- NK Activation Signaling · correlation 0.75
- NK Activation Signaling · correlation 0.73
- KIR+ NK Maturation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.