MLC1 — Modulator of VRAC current 1
MLC1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MLC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Terminal Differentiation T cell maturation | EPB41L4A, FCRL6, JAZF1, LILRB1, PRR5L, SYT11, ZEB2 | |
| Natural Killer cells | NK Homing Adhesion Homing & TEM | CHST2, IGFBP7, ITGAM, LAIR1, MYOM2, NCR3, SPN | View in SCUBA |
About the gene
| Synonyms | KIAA0027, LVM, MLC, VL |
|---|---|
| Chromosome | 22: 50059391-50085426 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
Function
Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain- cerebrospinal fluid barriers. Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. May function as regulatory protein of membrane protein complexes such as ion channels (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.